Early emollient bathing is associated with subsequent atopic dermatitis in an unselected birth cohort study

Background Skin barrier dysfunction is a key component of the pathogenesis atopic dermatitis (AD). Recent research on optimization to prevent AD has shown mixed results. The aim this study was assess relationship between emollient bathing at 2 months and trajectory in first years life large unselected observational birth cohort study. Methods Babies After SCOPE: Evaluating Longitudinal Impact Using Neurological Nutritional Endpoints Birth Cohort enrolled 2183 infants. Variables extracted from database related early skincare, skin function, parental history atopy, outcomes. Statistical analysis performed adjust for potential confounding variables. Results One thousand five hundred children had data status available 6, 12, 24 months. Prevalence 18.6% 6 months, 15.2% 12 16.5% Adjusted variables, odds any point were higher among infants who baths (OR (95% CI): 2.41 (1.56 3.72), p < .001). Following multivariable analysis, both frequent application compared with neither CI) 1.74 (1.18–2.58), = .038), 2.59 (1.69–3.94), .001), 1.87 (1.21–2.90), .009). Conclusion Early associated greater development by age population-based